Internship: Molecular Interaction Analysis to Delucidate Pathogenic Mechanism (Candidati appartenenti a Categorie Protette L. 68/99), Italy - 2024 - #10490461

GSK


Data: 1 settimana fa
città: Siena, Toscana
Tipo di contratto: Tempo pieno
Site Name: Italy - Siena
Posted Date: Apr 2 2024


Posting Title: Internship as
Molecular Interaction Analysis to Delucidate Pathogenic Mechanisms

Help us get ahead of disease together with our IT Protein Biochemistry Team

Education required: Master's Degree in Biotechnology, Microbiology and Biochemistry (preferred). Biology or CTF

Other requirements:

  • Experience in studies of molecular interactions between proteins or proteins and antibodies

  • Sound scientific methodology, critical thinking, and problem-solving skills

  • Microbiological and biochemical knowledge with a special focus on gram negative bacteria, recombinant proteins, vesicles

  • Basic expression and purification techniques

  • Ability to make molarity calculations for the preparation of solutions and buffers and for diluting, quantifying and dispensing proteic material

  • Fluent English and Italian

Preferred Qualifications:

  • Appartenenza alle cat. prot. L.68/99

Application deadline: April 16th

Duration: 6 Months

Start date: June 2024

Type: Extra-Curricular Internship

Looking to gain valuable real world work experience and help positively impact the health of billions of people? Apply for a GSK Internship today!

A GSK internship offers you the opportunity to kickstart your career – to take on a real role with genuine impact! You’ll take on challenging, serious work on live projects or assignments. You’ll also get to learn from us, develop your skills and gain valuable experience for wherever the future takes you.

What will you do?

Context

Fermentation, protein purification and analytics team (FPPA lab) operating within the Antigen Design function in Research department is mainly involved in the production, purification, analytical and functional characterization of novel proteic vaccine candidates with the perspective of process transfer at manufacturing scale.

The intern will initially be supported by experienced scientists of the laboratory to learn the fermentation and chromatographic techniques necessary for the production and the purification of the antigen of interest.

Project intern description

The project has the objective to exploit the antigen expression profiles in different bacterial compartments with a special focus on membrane extracts from a subset of bacterial strains cultured with different media/conditions/nutrients. The candidate will evaluate the effect of different media, nutrients and co-factors on the expression and localization of specific antigens in E. coli and Klebsiella pneumoniae.

Subsequently he/she attempt the enrichment or the purification of target antigens for analytical characterization and immunogenicity studies.

Competencies the intern will develop thanks to the internship experience:

Learn and understand the techniques of fermentation, purification, and basic analytical characterization of proteic antigens. In particular, the student will learn how to grow gram negative bacteria in flask and in bioreactor, affinity and hydrophobic chromatography, SE-HPLC, SDS-page, western blot, quantification methods. All these techniques will allow him/her to produce and characterize antigens that can be used as vaccine candidate.

Let’s do this!

You’ll find hints, tips and guidance on our recruitment process on our website –

Learn more about the application process | GSK


We recommend you apply as soon as possible, because we accept ongoing applications and offer positions on a first come, first served basis.

Apply now!

Need help with your application?

Please email us at [email protected] and let us know how we can help you.

Why Us?

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting For the Record site.

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